Methotrexate and bone marrow suppression: Standard collaborative care will be made more difficult

The Role of Bone Marrow Aspiration and Bone Marrow Biopsy in Diagnosis of Bone Marrow Metastases

Background: Bone marrow is the site of many malignant disorders and it is one of the common places for solid tumors to metastasize. Examination of the bone marrow aspirate and biopsy is a routine procedure performed for assessment of various conditions such as cytopenias, hematologic neoplasms, nonmalignant disorders and metastatic neoplasms. Methods: The patients were referred to the Hema...

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Protection of bone marrow transplant recipients from lethal doses of methotrexate by the generation of methotrexate-resistant bone marrow

To develop a highly efficient means for generating methotrexate resistant (MTXr) hematopoietic cells in vivo, a recombinant retroviral genome was constructed that encodes a MTXr dihydrofolate reductase (DHFRr). Cell lines producing high titers of virus capable of transmitting the DHFR gene were generated and used to infect mammalian cells in vitro. Analysis of infected fibroblasts indicated tha...

Nurse and Bone Marrow Transplant

پیوند مغز استخوان باید به مدت طولانی در بیمارستان بستری باشند، که این امر نیز موجب بروز برخی از عوارض روانی مانند: افسردگی، اضطراب، کج خلقی، ترس و ناامیدی در آنان خواهد شد. هرچند که برخورد صحیح کادر مراقبتی درمانی می تواند تا حد زیادی از این عوارض پیشگیری کند. در این مسیر تقویت اعتماد، اعتقاد، امید و تلاش برای سازگاری با مشکل ضرورت دارد. امروزه بسیاری از بیماریهای بدخیم به درمان با پیوند مغز اس...